High-intensity ultrasound confirms new treatment for Alzheimer's disease
Jan 20, 2025
A research team led by Professor Jang Jin-woo of Neurosurgery at Korea University Anam Hospital confirmed the clinical applicability of cerebrovascular barrier opening using high-intensity ultrasound in Alzheimer's disease.
A research team led by Professor Jang Jin-woo, Professor Ye Byung-seok of the Department of Neurology at Severance Hospital, and Professor Jang Kyung-won of the Department of Neurology at Samsung Medical Center confirmed that the treatment to open the cerebrovascular barrier with repeated high-intensity ultrasound is safe and has the effect of improving some neurological symptoms. The study was conducted with the support of the FUS Foundation (USA).
Amyloid beta plaques are toxic substances that cause Alzheimer's. Until now, attempts have been made to remove it by treatment using drugs, but it is difficult to deliver drugs due to various obstacles such as cerebrovascular barriers, and the treatment effect is limited due to side effects caused by drugs. Accordingly, the need to develop new treatments has been steadily raised.
Professor Jang Jin-woo's research team conducted three cerebrovascular barrier opening procedures using high-intensity ultrasound on six Alzheimer's disease patients every two months from June 2022 to July 2023. Various evaluations were conducted, including the Caregiver-Administered Neurological Inventory (CGA-NPI), which assesses non-cognitive symptoms such as changes in amyloid beta plaques before and after surgery and patients' behavior and psychology.
As a result of the study, it was confirmed that the frontal cerebrovascular barrier of 6 patients after surgery was temporarily opened on average 43.1 ㎤. In addition, in 4 out of 6 patients, amyloid beta plaques decreased by an average of 14.9 centiloid. In five of the six patients (83%), the neuropsychiatric symptoms such as delusion, anxiety, irritation, and anxiety in the CGA-NPI fell from 6.3 to 2.8 points, and the patient's behavior and psychological condition improved.
Professor Jang Jin-woo "This study partially confirmed the applicability of cerebrovascular barrier opening using high-intensity ultrasound for intractable neurological diseases such as Alzheimer's disease."We intend to develop cerebrovascular barrier opening to become one of the treatment strategies that can be used in clinical practice in the future through various additional clinical studies in the future."
The findings of this study by Professor Jang Jin-woo's team were recently published in the global journal Journal of Neurosurgery 'Journal of Neurosurgery'.
A research team led by Professor Jang Jin-woo, Professor Ye Byung-seok of the Department of Neurology at Severance Hospital, and Professor Jang Kyung-won of the Department of Neurology at Samsung Medical Center confirmed that the treatment to open the cerebrovascular barrier with repeated high-intensity ultrasound is safe and has the effect of improving some neurological symptoms. The study was conducted with the support of the FUS Foundation (USA).
Amyloid beta plaques are toxic substances that cause Alzheimer's. Until now, attempts have been made to remove it by treatment using drugs, but it is difficult to deliver drugs due to various obstacles such as cerebrovascular barriers, and the treatment effect is limited due to side effects caused by drugs. Accordingly, the need to develop new treatments has been steadily raised.
Professor Jang Jin-woo's research team conducted three cerebrovascular barrier opening procedures using high-intensity ultrasound on six Alzheimer's disease patients every two months from June 2022 to July 2023. Various evaluations were conducted, including the Caregiver-Administered Neurological Inventory (CGA-NPI), which assesses non-cognitive symptoms such as changes in amyloid beta plaques before and after surgery and patients' behavior and psychology.
As a result of the study, it was confirmed that the frontal cerebrovascular barrier of 6 patients after surgery was temporarily opened on average 43.1 ㎤. In addition, in 4 out of 6 patients, amyloid beta plaques decreased by an average of 14.9 centiloid. In five of the six patients (83%), the neuropsychiatric symptoms such as delusion, anxiety, irritation, and anxiety in the CGA-NPI fell from 6.3 to 2.8 points, and the patient's behavior and psychological condition improved.
Professor Jang Jin-woo "This study partially confirmed the applicability of cerebrovascular barrier opening using high-intensity ultrasound for intractable neurological diseases such as Alzheimer's disease."We intend to develop cerebrovascular barrier opening to become one of the treatment strategies that can be used in clinical practice in the future through various additional clinical studies in the future."
The findings of this study by Professor Jang Jin-woo's team were recently published in the global journal Journal of Neurosurgery 'Journal of Neurosurgery'.
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This article was translated by Naver AI translator.